ACTH 1-39
Adrenocorticotropic hormone
Full-length 39-amino-acid pituitary hormone that binds the MC2R receptor on adrenal cells, studied in cortisol and steroid production research.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- Adrenocorticotropic hormone
- Category
- Reproductive & Endocrine
- Type
- Single compound
- Development and regulatory status
- Corticotropin gel approved; ACTH 1-39 peptide is a research reagent
What researchers study
Full-length 39-amino-acid adrenocorticotropic hormone made by the pituitary. It binds the melanocortin-2 receptor (MC2R) on adrenal cortex cells, stimulating cortisol and other steroid production, and also acts on other melanocortin receptors.
Research areas
- Adrenal-axis and MC2R studies
- Immunomodulation beyond steroidogenesis
- Melanocortin receptor activation in immune cells
- Infantile spasms trial comparisons
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- review
Repository corticotropin gel, a complex mixture of ACTH analogues and other pituitary peptides, has been FDA-approved since 1952 and is thought to act through melanocortin receptors
- review
Preclinical and clinical studies reviewed showed immunomodulatory effects of the gel distinct from those of corticosteroids
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- PT-141melanocortin agonist acting at MC3R and MC4R in the same receptor family
- Melanotan II (MT-2 Acetate)synthetic melanocortin agonist in the same receptor family
- Melanotan Isynthetic melanocortin agonist in the same receptor family
