AOD9604 AOD
hGH fragment analogue
Modified C-terminal fragment of human growth hormone with an added tyrosine, studied in mice for effects on fat oxidation.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- hGH fragment analogue
- Category
- Fat Metabolism & Lipotropics
- Type
- Single compound
- Abbreviation
- AOD
- Development and regulatory status
- Not approved as a drug; obesity development stopped in 2007
What researchers study
AOD9604 is a modified fragment from the C-terminal region of human growth hormone, with an added tyrosine. In mice it raised fat oxidation without the hyperglycaemia or cell-proliferation effects seen with intact hormone.
Research areas
- Lipolysis and fat oxidation in adipocytes and rodents
- Beta-3 adrenergic receptor role in lipolysis
- Comparison with intact growth hormone effects
- Structure-activity studies of hormone fragments
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- rodent
In obese mice, chronic exposure reduced body weight gain similarly to hGH, raised fat oxidation and plasma glycerol, and did not cause hyperglycaemia
- rodent
A closely related fragment (AOD9401) reduced weight gain and adipocyte diameter in obese Zucker rats without causing insulin resistance
- phase 2 trial
A 24-week phase 2b trial in 536 adults found no tested dose significantly different from placebo at its primary endpoint
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- HGH Fragment 176-191closely related C-terminal growth hormone fragment
- TesamorelinGHRH analogue acting on the growth hormone axis, complementary pathway
- MOTS-c (Human)mitochondrial peptide studied in metabolic regulation, a complementary pathway
- AOD + Tesamorelin + MOTS-ccatalogue blend that includes AOD9604
