Dermorphin DR
Mu-opioid agonist
Heptapeptide from Phyllomedusa sauvagei frog skin and prototype mu-selective opioid peptide, notable for a D-amino acid at position two.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Mu-opioid agonist
- Category
- Neuro, Cognitive & Sleep
- Type
- Single compound
- Abbreviation
- DR
- Development and regulatory status
- Not approved; amphibian-derived research peptide
What researchers study
Heptapeptide from the skin of Phyllomedusa sauvagei frogs and the prototype of a group of mu-selective opioid peptides. It carries a naturally occurring D-amino acid at position two, a feature shared with the related deltorphins.
Research areas
- Mu-opioid receptor binding and signalling assays
- Structure-activity studies of D-amino-acid peptides
- Analgesia pharmacology in animal models
- Amphibian skin peptide biochemistry
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- review
Reviews describe dermorphin as the prototype of mu-selective opioid heptapeptides found in Phyllomedusa frog skin
- review
Deltorphins from the same frogs share a D-amino acid at position two but are delta-selective
