Skin, Hair & Cosmetic Research blend
GHK-Cu + KPV CUV
Copper peptide + anti-inflammatory blend
Research blend of GHK-Cu, a copper tripeptide, and KPV, an alpha-MSH-derived tripeptide, studied for matrix remodelling and inflammatory signalling.
Evidence level. Evidence comes mainly from animal or other preclinical models. For a blend, the rating covers the combination itself; each component has its own profile. About the badges
- Class
- Copper peptide + anti-inflammatory blend
- Category
- Skin, Hair & Cosmetic
- Type
- Research blend
- Abbreviation
- CUV
- Development and regulatory status
- Not approved; research blend (GHK-Cu, KPV)
Blend composition
What researchers study
Research blend of GHK-Cu, a copper tripeptide linked to matrix remodelling, and KPV, an alpha-MSH-derived tripeptide linked to anti-inflammatory signalling. The components have been studied separately; no peer-reviewed data on the blend were located.
Research areas
- Combined matrix-remodelling and inflammation pathway studies
- Skin-repair models with inflammatory challenge
- Fibroblast and keratinocyte cell-culture assays
- Gut and skin inflammation models (KPV component)
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- literature search
No peer-reviewed study of the GHK-Cu and KPV combination was located, as evidence relates to the components studied separately
- review
A review of Connectivity Map data reported GHK changed expression of 31.2% of human genes by at least 50%
- rodent
In a 2024 mouse colitis study, a KPV-based nanoparticle reduced inflammatory cytokines and restored tight-junction proteins
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
