Kisspeptin-10 KS
KISS1R agonist
Ten-amino-acid active fragment of kisspeptin and KISS1R agonist, studied for stimulating hypothalamic GnRH neurons and pulsatile LH and FSH release.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- KISS1R agonist
- Category
- Reproductive & Endocrine
- Type
- Single compound
- Abbreviation
- KS
- Development and regulatory status
- Not approved; investigational peptide in human physiology studies
What researchers study
Ten-amino-acid active fragment of kisspeptin, the endogenous ligand of the KISS1R (GPR54) receptor. It stimulates hypothalamic GnRH neurons and so drives pulsatile LH and FSH release.
Research areas
- Reproductive-axis and GnRH-neuron studies
- Gonadotropin and testosterone responses in volunteers
- Oocyte maturation trigger research
- Cardiac fibroblast matrix biology
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- human trial
In 15 healthy men, acute kisspeptin-10 infusions dose-dependently increased LH, FSH and testosterone versus vehicle
- human trial
Repeated intermittent kisspeptin-10 infusion sustained gonadotropin and testosterone secretion in healthy men for 12 days
- review
Inactivating variants in kisspeptin signalling genes cause congenital hypogonadotropic hypogonadism and failed pubertal development
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- GonadorelinGnRH acting downstream of kisspeptin neurons at the pituitary
- HCGstandard oocyte-maturation trigger compared with kisspeptin in reproductive studies
- Triptorelin AcetateGnRH agonist trigger compared with kisspeptin in reproductive studies
