Pancragen PA
Bioregulator peptide
Synthetic bioregulator tetrapeptide Lys-Glu-Asp-Trp, described as a pancreatic regulator, studied in pancreatic cell cultures and diabetic rat models.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Bioregulator peptide
- Category
- Bioregulator Peptides
- Type
- Single compound
- Abbreviation
- PA
- Development and regulatory status
- Not approved by FDA or EMA, research-only bioregulator peptide
What researchers study
Synthetic amidated tetrapeptide Lys-Glu-Asp-Trp (KEDW) from the Khavinson programme, described as a pancreatic regulator. Reported to raise differentiation-factor expression in pancreatic cell cultures and to alter glucose handling in diabetic rats and ageing monkeys.
Research areas
- Pancreatic acinar and islet cell differentiation in culture
- Glucose tolerance in ageing rhesus monkeys
- Streptozotocin diabetes models in rats
- Insulin resistance in small elderly cohorts
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- cell culture
In ageing pancreatic cell cultures, Pancragen increased expression of differentiation factors including Pdx1, Ptf1a, Pax6 and Foxa2
- primate
In old female rhesus monkeys, the peptide was associated with faster glucose clearance and normalised insulin and C-peptide responses to a glucose load
- small human study
A small study in 30 healthy older adults and 33 with type 2 diabetes reported lower fasting glucose and insulin resistance index in peptide-treated patients
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- MelatoninNocturnal melatonin was measured alongside Pancragen in the elderly diabetes study
- BronchogenTested alongside Pancragen in a tissue-specific differentiation study of ageing cultures
- VesugenTested alongside Pancragen in a tissue-specific differentiation study of ageing cultures
