Somatropin (rHGH)
Recombinant growth hormone
Recombinant 191-amino-acid human growth hormone that binds the growth hormone receptor, activating JAK2-STAT5 signalling and IGF-1 production.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- Recombinant growth hormone
- Category
- Growth Hormone Axis
- Type
- Single compound
- Development and regulatory status
- Approved prescription drug (growth hormone deficiency and other indications)
What researchers study
Recombinant 191-amino-acid human growth hormone identical in sequence to the pituitary hormone. It binds the growth hormone receptor, activating JAK2-STAT5 signalling and stimulating IGF-1 production and growth.
Research areas
- GH receptor signalling in cell culture
- Growth and IGF-1 axis in animal models
- Long-acting versus daily GH formulation comparisons
- Tumour-cell migration and GH receptor studies
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- review
A network meta-analysis of 18 randomised trials (3,137 children with GH deficiency) used daily somatropin as the standard comparator for long-acting GH products
- human trial
A matched analysis compared three-year height outcomes with weekly somatrogon against historical daily-somatropin data from the KIGS registry
- review
A 2026 review describes GH receptor signalling as enhancing tumour-cell migration and IGF-1 and VEGF regulation in breast cancer models
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- IGF-1 LR3IGF-1 analogue acting on the pathway downstream of GH
- HGH Fragment 176-191GH fragment studied for metabolic effects distinct from the full hormone
- Tesamorelinstimulates endogenous GH release, contrasted with recombinant GH
- MK-677oral ghrelin mimetic compared for GH and IGF-1 axis effects
