BPC-157 BC
Pentadecapeptide
Synthetic 15-amino-acid peptide derived from a protein in human gastric juice, studied in rodent models for angiogenesis and nitric oxide pathways.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- Pentadecapeptide
- Category
- Tissue Repair & Recovery
- Type
- Single compound
- Abbreviation
- BC
- Development and regulatory status
- Not approved; investigational research compound with very limited human data
What researchers study
BPC-157 is a synthetic 15-amino-acid peptide whose sequence derives from a protein found in human gastric juice. In rodent studies it has been linked to angiogenesis signalling, nitric oxide pathways and growth-factor receptor expression.
Research areas
- Tendon and ligament healing in rodent injury models
- Gastrointestinal mucosal protection in animal models
- Angiogenesis and blood-vessel signalling studies
- Ischaemia-reperfusion injury models in rodents
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- review
A 2025 systematic review included 36 studies (35 preclinical, one clinical), and preclinical models reported improved muscle, tendon, ligament and bone outcomes
- review
A 2026 systematic review of human data found three small, uncontrolled studies (30 participants in total) of poor methodological quality
- review
In rodent ischaemia-reperfusion models BPC-157 has been associated with attenuated oxidative injury, though a 2026 critical review noted substantial heterogeneity across study designs
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- TB-500 (Thymosin Beta-4 Acetate)Actin-mediated cell migration complements BPC-157 angiogenic signalling in repair models
- GHK-CuMatrix-remodelling and collagen-synthesis pathways complement BPC-157 in wound-repair research
- KPVAlpha-MSH-derived anti-inflammatory signalling complements BPC-157 in gut-inflammation models
