TB-500 (Thymosin Beta-4 Acetate) TB

TB-500 is a synthetic peptide based on a fragment of thymosin beta-4, an actin-binding protein found in most cells. Analytical work identified the acetylated 17-23 sequence (Ac-LKKTETQ) in TB-500 preparations.

• Cell migration and actin dynamics in culture
• Angiogenesis assays in endothelial cells
• Dermal wound-healing models in rodents
• Myocardial injury models with parent thymosin beta-4

Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.

1. rodent

   In a rat full-thickness wound model, full-length thymosin beta-4 increased re-epithelialisation by 42% over saline at day 4 and by up to 61% at day 7

2. cell culture

   Full-length thymosin beta-4 stimulated keratinocyte migration 2- to 3-fold over medium alone in a Boyden chamber assay

3. analytical study

   A 2012 mass-spectrometry study identified the acetylated 17-23 fragment (Ac-LKKTETQ) in a product sold as TB-500

Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.

• BPC-157Angiogenic and cytoprotective signalling complements thymosin beta-4 migration effects in repair research
• GHK-CuCopper-peptide matrix remodelling alongside actin-driven cell migration in skin-repair models
• BPC-157 + TB-500Fixed combination of the two repair-pathway peptides