Cortagen COR
Bioregulator tetrapeptide
Synthetic bioregulator tetrapeptide Ala-Glu-Asp-Pro, designed from Cortexin, studied for nerve regeneration, brain ischaemia and gene expression.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Bioregulator tetrapeptide
- Category
- Bioregulator Peptides
- Type
- Single compound
- Abbreviation
- COR
- Development and regulatory status
- Not approved by FDA or EMA, research-only bioregulator peptide
What researchers study
Synthetic tetrapeptide Ala-Glu-Asp-Pro (AEDP), designed from amino-acid analysis of the natural brain-cortex peptide preparation Cortexin. Studied mainly by one research network for nerve regeneration, brain ischaemia and gene-expression effects.
Research areas
- Peripheral nerve regeneration in rats
- Chronic brain ischaemia and behaviour in rat models
- Heart-tissue gene-expression profiling in mice
- Immune-cell and chromatin responses in vitro
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- rodent
In a microarray study of mouse heart, peptide treatment changed expression of 110 known genes (234 clones among 15,247 transcripts screened)
- rodent
In rats with chronic brain ischaemia, Cortagen and the comparator Cortexin accelerated recovery of disturbed behaviour and limited lipid peroxidation in brain tissue
- evidence note
Authors report nerve-regeneration findings in rats and human observations, but no controlled human trial was retrieved
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- PinealonBoth are short brain-directed bioregulator peptides
- SemaxReviewed alongside Cortagen and Pinealon as a neuroprotective peptide
- EpitalonCompared with Cortagen in mouse heart and thymocyte studies
- CerebrolysinBrain polypeptide complex reviewed alongside short peptides such as Cortagen
