Epitalon ET
Tetrapeptide (pineal)
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied for telomerase induction in cultured human fibroblasts, with published work mostly from one group.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Tetrapeptide (pineal)
- Category
- Mitochondrial & Longevity
- Type
- Single compound
- Abbreviation
- ET
- Development and regulatory status
- Not approved; research peptide with limited published evidence
What researchers study
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from pineal-peptide research. Reported in human fibroblast cultures to induce telomerase and lengthen telomeres; most published work comes from one research group and independent replication is limited.
Research areas
- Telomerase expression in human cell culture
- Replicative lifespan of fibroblasts
- Ageing-pathway studies in animals
- Pineal-peptide bioregulation research
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- cell culture
In telomerase-negative human fetal fibroblasts, Epithalon induced telomerase catalytic subunit expression, enzyme activity and telomere elongation
- cell culture
Peptide-treated cells with elongated telomeres made 10 extra divisions, reaching 44 passages versus a 34-passage limit in aged cells
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
