Thymalin TY
Thymus-derived peptide complex
Calf thymus polypeptide extract reportedly containing Vilon, Thymogen and EDP, studied for T-lymphocyte differentiation and gene expression effects.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Thymus-derived peptide complex
- Category
- Bioregulator Peptides
- Type
- Single compound
- Abbreviation
- TY
- Development and regulatory status
- Registered in Russia (calf thymus extract), no FDA or EMA approval
What researchers study
Polypeptide extract of calf thymus whose reported components include the dipeptides KE (Vilon) and EW (Thymogen) and the tripeptide EDP. Proposed to modulate T-lymphocyte differentiation and gene expression, with most data from Russian research groups.
Research areas
- T-lymphocyte differentiation from hematopoietic stem cells
- Immune ageing in small elderly cohorts
- Inflammatory cytokine signalling in monocyte cell lines
- Tumour and thymus responses in rat sarcoma models
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- human study
A 6-8 year follow-up in older adults reported 2.0-2.1-fold lower mortality with Thymalin than controls, but randomisation and blinding are not described in the abstract
- cell culture
In human hematopoietic stem-cell cultures, Thymalin lowered CD44 and CD117 expression 2-3-fold and raised CD28, consistent with differentiation towards mature T cells
- rodent
In rats with transplanted sarcoma 45, tumour growth arrested or regressed in more than half of treated animals and was suppressed by 78% in others
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- EpitalonSynthetic pineal tetrapeptide, Thymalin plus pineal extract was studied together in older adults
- VilonKE dipeptide, a reported Thymalin component
- CrystagenEDP tripeptide, a reported Thymalin component
- Thymosin Alpha-1Separate thymic peptide with overlapping immune-regulation research focus
