Vitamin B-12 (large vial) B12
Cobalamin
Cobalt-containing vitamin (cobalamin) studied as a cofactor for methionine synthase and methylmalonyl-CoA mutase in methylation and metabolism.
Evidence level. Published human clinical data exists, from trials or approved use. About the badges
- Class
- Cobalamin
- Category
- Antioxidants & Specialty
- Type
- Single compound
- Abbreviation
- B12
- Development and regulatory status
- Essential vitamin; injectable forms approved for vitamin B12 deficiency
What researchers study
Cobalt-containing vitamin (cobalamin) that serves as a cofactor for methionine synthase, which supports methylation through homocysteine recycling, and for methylmalonyl-CoA mutase in fatty-acid and amino-acid metabolism.
Research areas
- Methylation and one-carbon metabolism assays
- Cell-culture medium supplementation
- Homocysteine and methylmalonic acid biomarkers
- Haematopoiesis and myelin biology models
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- review
A Cochrane review of vitamin B12 deficiency identified three randomised trials with 153 participants, too few and too varied for meta-analysis
- review
Outcomes assessed in such trials include serum B12, homocysteine and methylmalonic acid levels
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- MIC (Lipo-C with B12)Catalogue blend that includes vitamin B12
- Lipo-C with Vitamin B12Catalogue blend that includes vitamin B12
- GlutathioneMethylation cycle linked to cysteine supply for glutathione synthesis
