5-Amino-1MQ 5AM
NNMT inhibitor (small molecule)
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in fat-cell and energy metabolism research.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- NNMT inhibitor (small molecule)
- Category
- Fat Metabolism & Lipotropics
- Type
- Single compound
- Abbreviation
- 5AM
- Development and regulatory status
- Not approved; preclinical research compound
What researchers study
5-Amino-1-methylquinolinium is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that uses up methyl donors and nicotinamide. Researchers study NNMT inhibition in fat-cell and energy metabolism.
Research areas
- NNMT inhibition and methyl-donor metabolism
- Adipocyte lipogenesis in cell culture
- Diet-induced obesity in mouse models
- NAD+ and SAM pathway biology
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- rodent
In diet-induced obese mice, NNMT inhibitor exposure reduced body weight, white adipose mass and adipocyte size, and lowered plasma total cholesterol, without changing food intake
- cell culture
In cultured adipocytes, NNMT inhibitors suppressed lipogenesis, lowered 1-methylnicotinamide and raised NAD+ and SAM levels
- literature check
No controlled human trial data were identified
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
- NAD+ + MOTS-c + 5-Amino-1MQcatalogue blend that includes 5-Amino-1MQ
- NAD+NNMT inhibition raised NAD+ levels in cultured adipocytes, a linked pathway
- MOTS-c (Human)mitochondrial peptide studied in metabolic regulation, a complementary pathway
