Vilon VI
Bioregulator dipeptide
Synthetic bioregulator dipeptide Lys-Glu, a reported Thymalin component, studied for lymphocyte differentiation and gene expression in cultures.
Evidence level. Evidence comes mainly from animal or other preclinical models. About the badges
- Class
- Bioregulator dipeptide
- Category
- Bioregulator Peptides
- Type
- Single compound
- Abbreviation
- VI
- Development and regulatory status
- Not approved by FDA or EMA, research-only bioregulator peptide
What researchers study
Synthetic dipeptide Lys-Glu (KE) from the Khavinson programme, studied as a thymus-related immune peptide and reported as a Thymalin component. Reported to affect lymphocyte differentiation and gene expression in cultures, mostly in work from one research network.
Research areas
- Thymocyte and spleen-cell proliferation in organotypic culture
- T-cell differentiation in pineal lymphoid tissue culture
- Cytokine expression in LPS-stimulated THP-1 cells
- Gene expression in ageing stem-cell cultures
Reported findings
Summaries of published results. Each one is tagged with the type of study behind it. They describe research outcomes and are not claims about any product. Why study type matters.
- cell culture
In mouse thymocytes, Vilon had the strongest comitogenic effect of three short peptides tested and raised sphingomyelinase activity in membranes
- cell culture
In pineal lymphoid-tissue organotypic culture, Vilon stimulated differentiation of precursors into T-helpers, cytotoxic T cells and B cells
- cell culture
In THP-1 cells, Vilon and four other Khavinson peptides inhibited LPS-stimulated TNF and IL-6 expression in differentiated cells
Studied alongside
Compounds that appear together in research because their mechanisms complement each other, or as comparators. The reasons given are research reasoning, not recommendations for use.
